Drug interactions
Glyburide-metformin + Phenytoin
Severity: Moderate
Glyburide-metformin and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces hepatic metabolism of glyburide and can also raise blood glucose by inhibiting insulin release. Both effects can reduce glycemic control in patients taking glyburide-metformin.
What this interaction means in plain words
Glyburide-metformin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Phenytoin belongs to Central Nervous System.
Why it happens
CYP2C9 induction by phenytoin increases glyburide clearance, and phenytoin inhibits insulin secretion.
What to do
Monitor blood glucose when phenytoin is started or stopped and adjust antidiabetic doses; watch for hypoglycemia after phenytoin is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Phenytoin?
MediHelp rates the interaction as moderate. Glyburide-metformin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin induces hepatic metabolism of glyburide and can also raise blood glucose by inhibiting insulin release. Both effects can reduce glycemic control in patients taking glyburide-metformin.
How serious is the interaction between Glyburide-metformin and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when phenytoin is started or stopped and adjust antidiabetic doses; watch for hypoglycemia after phenytoin is withdrawn.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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