Drug interactions
Glyburide-metformin + Pindolol
Severity: Moderate
Glyburide-metformin and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nonselective beta blockers can mask adrenergic warning signs of hypoglycemia and prolong recovery. Glyburide increases the risk of significant hypoglycemia.
What this interaction means in plain words
Glyburide-metformin and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-adrenergic blockade blunts tachycardia and tremor and impairs glycogenolysis during hypoglycemia.
What to do
Counsel patients that sweating may be the main hypoglycemia sign, monitor glucose, and consider a cardioselective alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Pindolol?
MediHelp rates the interaction as moderate. Glyburide-metformin and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nonselective beta blockers can mask adrenergic warning signs of hypoglycemia and prolong recovery. Glyburide increases the risk of significant hypoglycemia.
How serious is the interaction between Glyburide-metformin and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients that sweating may be the main hypoglycemia sign, monitor glucose, and consider a cardioselective alternative.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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