Drug interactions
Glyburide-metformin + Propranolol
Severity: Moderate
Glyburide-metformin and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol can blunt the warning signs of hypoglycemia such as tremor and palpitations, while sweating is preserved. It may also prolong recovery from hypoglycemia and slightly impair glycemic control, which matters in patients on a sulfonylurea.
What this interaction means in plain words
Glyburide-metformin and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Propranolol belongs to Cardiovascular.
Why it happens
Non-selective beta blockade masks adrenergic hypoglycemia symptoms and impairs glycogenolysis and counter-regulatory response.
What to do
Counsel patients to rely on sweating and glucose readings rather than adrenergic symptoms, and monitor blood glucose more often when starting or changing propranolol. Consider a cardioselective beta blocker if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Glyburide-metformin with Propranolol?
MediHelp rates the interaction as moderate. Glyburide-metformin and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propranolol can blunt the warning signs of hypoglycemia such as tremor and palpitations, while sweating is preserved. It may also prolong recovery from hypoglycemia and slightly impair glycemic control, which matters in patients on a sulfonylurea.
How serious is the interaction between Glyburide-metformin and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to rely on sweating and glucose readings rather than adrenergic symptoms, and monitor blood glucose more often when starting or changing propranolol. Consider a cardioselective beta blocker if one is needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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