Drug interactions
Glyburide-metformin + Quinapril
Severity: Moderate
Glyburide-metformin and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and may increase the glucose-lowering effect of glyburide, raising hypoglycemia risk. Renal impairment from ACE inhibitors could also raise metformin accumulation risk.
What this interaction means in plain words
Glyburide-metformin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Improved insulin sensitivity adds to sulfonylurea effect; ACE inhibitor-related reduction in renal function may reduce metformin clearance.
What to do
Monitor glucose and renal function, especially at initiation, and reduce glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Quinapril?
MediHelp rates the interaction as moderate. Glyburide-metformin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and may increase the glucose-lowering effect of glyburide, raising hypoglycemia risk. Renal impairment from ACE inhibitors could also raise metformin accumulation risk.
How serious is the interaction between Glyburide-metformin and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function, especially at initiation, and reduce glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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