Drug interactions
Glyburide-metformin + Rifampin
Severity: Moderate
Glyburide-metformin and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces hepatic enzymes and lowers glyburide exposure, reducing glycemic control. Hypoglycemia can occur when rifampin is stopped.
What this interaction means in plain words
Glyburide-metformin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP2C9 and CYP3A4 increases glyburide metabolism, and transporter effects may also contribute.
What to do
Monitor blood glucose when rifampin is started or stopped and increase or decrease the antidiabetic dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Rifampin?
MediHelp rates the interaction as moderate. Glyburide-metformin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces hepatic enzymes and lowers glyburide exposure, reducing glycemic control. Hypoglycemia can occur when rifampin is stopped.
How serious is the interaction between Glyburide-metformin and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when rifampin is started or stopped and increase or decrease the antidiabetic dose accordingly.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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