Drug interactions
Glyburide-metformin + Sacubitril / valsartan
Severity: Minor
Glyburide-metformin and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide may inhibit hepatic OATP1B1 and could raise valsartan exposure. The clinical effect is likely small and mainly a modest increase in blood pressure lowering.
What this interaction means in plain words
Glyburide-metformin and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of valsartan by glyburide.
What to do
No routine adjustment is needed. Monitor blood pressure and renal function as for standard sacubitril/valsartan therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Glyburide-metformin and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glyburide may inhibit hepatic OATP1B1 and could raise valsartan exposure. The clinical effect is likely small and mainly a modest increase in blood pressure lowering.
How serious is the interaction between Glyburide-metformin and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor blood pressure and renal function as for standard sacubitril/valsartan therapy.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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