Drug interactions
Glyburide-metformin + Sofosbuvir / velpatasvir
Severity: Moderate
Glyburide-metformin and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits BCRP and other transporters, which may increase glyburide exposure. Also, improved glycemic control often follows hepatitis C cure, which may lower insulin or drug requirements.
What this interaction means in plain words
Glyburide-metformin and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Velpatasvir inhibits BCRP and OATP transporters, possibly raising glyburide levels.
What to do
Monitor blood glucose for hypoglycemia during and after hepatitis C treatment and reduce the antidiabetic dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Glyburide-metformin and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir inhibits BCRP and other transporters, which may increase glyburide exposure. Also, improved glycemic control often follows hepatitis C cure, which may lower insulin or drug requirements.
How serious is the interaction between Glyburide-metformin and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose for hypoglycemia during and after hepatitis C treatment and reduce the antidiabetic dose if needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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