Drug interactions
Glyburide-metformin + Sulfadiazine
Severity: Moderate
Glyburide-metformin and Sulfadiazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfadiazine may increase glyburide exposure and effect, raising the risk of hypoglycemia, which can be prolonged or severe.
What this interaction means in plain words
Glyburide-metformin and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfonamide inhibition of CYP2C9 and displacement from plasma protein binding raise glyburide levels.
What to do
Monitor blood glucose closely and reduce the glyburide dose if hypoglycemia occurs. Warn the patient about hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Sulfadiazine?
MediHelp rates the interaction as moderate. Glyburide-metformin and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfadiazine may increase glyburide exposure and effect, raising the risk of hypoglycemia, which can be prolonged or severe.
How serious is the interaction between Glyburide-metformin and Sulfadiazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the glyburide dose if hypoglycemia occurs. Warn the patient about hypoglycemia symptoms.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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