Drug interactions
Glyburide-metformin + Sulfamethoxazole
Severity: Major
Glyburide-metformin and Sulfamethoxazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole can potentiate glyburide, and cases of significant hypoglycemia have been reported, particularly in older patients or those with renal impairment.
What this interaction means in plain words
Glyburide-metformin and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Sulfamethoxazole inhibits CYP2C9 and displaces glyburide from protein binding, raising its exposure.
What to do
Monitor blood glucose closely during co-trimoxazole therapy and reduce the glyburide dose or use an alternative antibiotic where possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Sulfamethoxazole?
MediHelp rates the interaction as major. Glyburide-metformin and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sulfamethoxazole can potentiate glyburide, and cases of significant hypoglycemia have been reported, particularly in older patients or those with renal impairment.
How serious is the interaction between Glyburide-metformin and Sulfamethoxazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during co-trimoxazole therapy and reduce the glyburide dose or use an alternative antibiotic where possible.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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