Drug interactions
Glyburide-metformin + Sulfisoxazole
Severity: Moderate
Glyburide-metformin and Sulfisoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfisoxazole may increase glyburide effect and cause hypoglycemia.
What this interaction means in plain words
Glyburide-metformin and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Displacement of glyburide from plasma proteins and possible CYP2C9 inhibition.
What to do
Monitor blood glucose and reduce the glyburide dose if hypoglycemia appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Sulfisoxazole?
MediHelp rates the interaction as moderate. Glyburide-metformin and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfisoxazole may increase glyburide effect and cause hypoglycemia.
How serious is the interaction between Glyburide-metformin and Sulfisoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the glyburide dose if hypoglycemia appears.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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