Drug interactions
Glyburide-metformin + Tenofovir df
Severity: Moderate
Glyburide-metformin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir DF may modestly raise metformin exposure and can itself affect renal function, which increases concern for metformin accumulation and lactic acidosis in susceptible patients.
What this interaction means in plain words
Glyburide-metformin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible competition for renal tubular transporters and tenofovir-related nephrotoxicity reduce metformin clearance.
What to do
Monitor renal function periodically and adjust or stop metformin if eGFR falls. Counsel on symptoms of lactic acidosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Tenofovir df?
MediHelp rates the interaction as moderate. Glyburide-metformin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir DF may modestly raise metformin exposure and can itself affect renal function, which increases concern for metformin accumulation and lactic acidosis in susceptible patients.
How serious is the interaction between Glyburide-metformin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function periodically and adjust or stop metformin if eGFR falls. Counsel on symptoms of lactic acidosis.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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