Drug interactions
Glyburide-metformin + Trifluoperazine
Severity: Moderate
Glyburide-metformin and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as trifluoperazine can impair glucose tolerance and may reduce the effect of antidiabetic drugs, leading to hyperglycemia.
What this interaction means in plain words
Glyburide-metformin and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Phenothiazines may reduce insulin secretion and sensitivity, opposing hypoglycemic agents.
What to do
Monitor blood glucose when trifluoperazine is started or changed and adjust antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Trifluoperazine?
MediHelp rates the interaction as moderate. Glyburide-metformin and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines such as trifluoperazine can impair glucose tolerance and may reduce the effect of antidiabetic drugs, leading to hyperglycemia.
How serious is the interaction between Glyburide-metformin and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when trifluoperazine is started or changed and adjust antidiabetic doses as needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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