Drug interactions
Glyburide-metformin + Willow bark
Severity: Minor
Glyburide-metformin and Willow bark: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, which is converted to salicylate. Salicylates can enhance the hypoglycemic effect of sulfonylureas such as glyburide, especially at large doses.
What this interaction means in plain words
Glyburide-metformin and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylate displacement of glyburide from plasma proteins and an intrinsic glucose-lowering effect.
What to do
Monitor blood glucose if willow bark is taken regularly, and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Glyburide-metformin with Willow bark?
MediHelp rates the interaction as minor. Glyburide-metformin and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Willow bark contains salicin, which is converted to salicylate. Salicylates can enhance the hypoglycemic effect of sulfonylureas such as glyburide, especially at large doses.
How serious is the interaction between Glyburide-metformin and Willow bark?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if willow bark is taken regularly, and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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