Drug interactions
Glycerol phenylbutyrate + Pimozide
Severity: Minor
Glycerol phenylbutyrate and Pimozide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycerol phenylbutyrate is a weak CYP3A4 inducer and may reduce plasma concentrations of CYP3A4 substrates. Pimozide exposure could fall and reduce its effect on tics or psychosis.
What this interaction means in plain words
Glycerol phenylbutyrate and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glycerol phenylbutyrate belongs to Miscellaneous; Pimozide belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 increases pimozide metabolism.
What to do
Monitor for reduced clinical response to pimozide after starting glycerol phenylbutyrate and adjust the dose to effect, with ECG monitoring if the dose is raised.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Major
- Glycerol phenylbutyrate + Sodium valproate Major
- Glycerol phenylbutyrate + Valproic acid Major
- Cyclosporin + Glycerol phenylbutyrate Moderate
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderate
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderate
Frequently asked questions
Can I take Glycerol phenylbutyrate with Pimozide?
MediHelp rates the interaction as minor. Glycerol phenylbutyrate and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glycerol phenylbutyrate is a weak CYP3A4 inducer and may reduce plasma concentrations of CYP3A4 substrates. Pimozide exposure could fall and reduce its effect on tics or psychosis.
How serious is the interaction between Glycerol phenylbutyrate and Pimozide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced clinical response to pimozide after starting glycerol phenylbutyrate and adjust the dose to effect, with ECG monitoring if the dose is raised.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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