Drug interactions
Glyceryl trinitrate pr + Vardenafil
Severity: Contraindicated
Glyceryl trinitrate pr and Vardenafil: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vardenafil potentiates the vasodilating effect of nitrates, including rectal glyceryl trinitrate. The result can be severe, potentially fatal hypotension, syncope or myocardial ischemia.
What this interaction means in plain words
Glyceryl trinitrate pr and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
PDE5 inhibition prevents cGMP breakdown, amplifying nitric-oxide-mediated vasodilation from the nitrate.
What to do
Do not use together. Avoid nitrates for at least 24 hours after vardenafil, and seek urgent care if chest pain occurs after a dose.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
- Nitroglycerin rectal + Vardenafil Contraindicated
Frequently asked questions
Can I take Glyceryl trinitrate pr with Vardenafil?
MediHelp rates the interaction as contraindicated. Glyceryl trinitrate pr and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vardenafil potentiates the vasodilating effect of nitrates, including rectal glyceryl trinitrate. The result can be severe, potentially fatal hypotension, syncope or myocardial ischemia.
How serious is the interaction between Glyceryl trinitrate pr and Vardenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Avoid nitrates for at least 24 hours after vardenafil, and seek urgent care if chest pain occurs after a dose.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Vardenafil page.
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