Drug interactions
Glycopyrrolate inhaled + Imipramine
Severity: Minor
Glycopyrrolate inhaled and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled glycopyrrolate has low systemic absorption but still contributes some antimuscarinic effect. With imipramine, additive dry mouth, urinary retention and constipation are possible.
What this interaction means in plain words
Glycopyrrolate inhaled and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antimuscarinic effects, limited by low systemic exposure to the inhaled drug.
What to do
Monitor for urinary retention and other anticholinergic symptoms, particularly in older men with prostatic enlargement.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Glycopyrrolate inhaled with Imipramine?
MediHelp rates the interaction as minor. Glycopyrrolate inhaled and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Inhaled glycopyrrolate has low systemic absorption but still contributes some antimuscarinic effect. With imipramine, additive dry mouth, urinary retention and constipation are possible.
How serious is the interaction between Glycopyrrolate inhaled and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention and other anticholinergic symptoms, particularly in older men with prostatic enlargement.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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