Drug interactions
Glycopyrrolate inhaled + Promethazine
Severity: Minor
Glycopyrrolate inhaled and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have antimuscarinic effects, and although inhaled glycopyrrolate has low systemic exposure, additive anticholinergic effects such as dry mouth, urinary retention and constipation may occur. The clinical impact is usually modest.
What this interaction means in plain words
Glycopyrrolate inhaled and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive muscarinic receptor blockade, with limited systemic contribution from the inhaled route.
What to do
Monitor for anticholinergic symptoms, particularly urinary retention and constipation in older patients or those with glaucoma.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Glycopyrrolate inhaled with Promethazine?
MediHelp rates the interaction as minor. Glycopyrrolate inhaled and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have antimuscarinic effects, and although inhaled glycopyrrolate has low systemic exposure, additive anticholinergic effects such as dry mouth, urinary retention and constipation may occur. The clinical impact is usually modest.
How serious is the interaction between Glycopyrrolate inhaled and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms, particularly urinary retention and constipation in older patients or those with glaucoma.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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