Drug reference
promethazine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Respiratory (Anti Histamine)
Mechanism of action
Promethazine competes with histamine for the histamine H1 receptor, reversible competitive inhibitor.
Common side effects
- Sedation
- Drowsiness
- children less than two it can depress respiration
- Dry Mouth
Known interactions (3)
- epinephrine + promethazine Major
- indapamide + promethazine Moderate
- Levocetirizine + promethazine Moderate
Related conditions
Frequently asked questions
What drug class is promethazine?
promethazine belongs to: Respiratory.
How does promethazine work?
Promethazine competes with histamine for the histamine H1 receptor, reversible competitive inhibitor.
What are the common side effects of promethazine?
Sedation, Drowsiness, children less than two it can depress respiration, Dry Mouth
Which drugs interact with promethazine?
epinephrine, indapamide, Levocetirizine
Full monographs, dosing and an interaction checker in the MediHelp app
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