Drug interactions
Glycopyrrolate inhaled + Tolterodine
Severity: Moderate
Glycopyrrolate inhaled and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled glycopyrrolate has some systemic absorption and adds antimuscarinic effects to oral tolterodine. This may increase dry mouth, urinary retention and constipation.
What this interaction means in plain words
Glycopyrrolate inhaled and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for urinary retention, constipation and dry mouth, especially in older men with prostatic enlargement; reduce or stop one agent if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Glycopyrrolate inhaled with Tolterodine?
MediHelp rates the interaction as moderate. Glycopyrrolate inhaled and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled glycopyrrolate has some systemic absorption and adds antimuscarinic effects to oral tolterodine. This may increase dry mouth, urinary retention and constipation.
How serious is the interaction between Glycopyrrolate inhaled and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation and dry mouth, especially in older men with prostatic enlargement; reduce or stop one agent if symptomatic.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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