Drug interactions
Glycopyrronium tosylate + Imipramine
Severity: Moderate
Glycopyrronium tosylate and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycopyrronium tosylate is a topical anticholinergic used for axillary hyperhidrosis, and its systemic absorption is limited but present. With imipramine, additive anticholinergic effects such as dry mouth, urinary retention and blurred vision are possible.
What this interaction means in plain words
Glycopyrronium tosylate and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic adverse effects and stop the topical product if urinary retention or marked symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glycopyrronium tosylate and Imipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Glycopyrronium tosylate with Imipramine?
MediHelp rates the interaction as moderate. Glycopyrronium tosylate and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycopyrronium tosylate is a topical anticholinergic used for axillary hyperhidrosis, and its systemic absorption is limited but present. With imipramine, additive anticholinergic effects such as dry mouth, urinary retention and blurred vision are possible.
How serious is the interaction between Glycopyrronium tosylate and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and stop the topical product if urinary retention or marked symptoms occur.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
