Drug interactions
Glycopyrronium tosylate + Nortriptyline
Severity: Moderate
Glycopyrronium tosylate and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical glycopyrronium tosylate is applied to the skin for hyperhidrosis and can be absorbed to a small extent. Nortriptyline's anticholinergic activity may add to systemic effects such as dry mouth, blurred vision and urinary retention.
What this interaction means in plain words
Glycopyrronium tosylate and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic effects including urinary hesitancy, constipation and blurred vision. Stop the topical product if significant symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Glycopyrronium tosylate with Nortriptyline?
MediHelp rates the interaction as moderate. Glycopyrronium tosylate and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topical glycopyrronium tosylate is applied to the skin for hyperhidrosis and can be absorbed to a small extent. Nortriptyline's anticholinergic activity may add to systemic effects such as dry mouth, blurred vision and urinary retention.
How serious is the interaction between Glycopyrronium tosylate and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects including urinary hesitancy, constipation and blurred vision. Stop the topical product if significant symptoms develop.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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