Drug interactions
Glycopyrronium tosylate + Promethazine
Severity: Minor
Glycopyrronium tosylate and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical glycopyrronium tosylate has some systemic absorption and can cause anticholinergic effects, which may be additive with the antimuscarinic activity of promethazine. This can lead to dry mouth, blurred vision, urinary retention or constipation.
What this interaction means in plain words
Glycopyrronium tosylate and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic adverse effects and reduce use of one agent if bothersome symptoms such as urinary retention or blurred vision develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Glycopyrronium tosylate with Promethazine?
MediHelp rates the interaction as minor. Glycopyrronium tosylate and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Topical glycopyrronium tosylate has some systemic absorption and can cause anticholinergic effects, which may be additive with the antimuscarinic activity of promethazine. This can lead to dry mouth, blurred vision, urinary retention or constipation.
How serious is the interaction between Glycopyrronium tosylate and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and reduce use of one agent if bothersome symptoms such as urinary retention or blurred vision develop.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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