Drug interactions
Glycopyrronium tosylate + Tolterodine
Severity: Moderate
Glycopyrronium tosylate and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, and topical glycopyrronium has some systemic absorption. Combined use may cause additive dry mouth, constipation, urinary retention, blurred vision and heat intolerance.
What this interaction means in plain words
Glycopyrronium tosylate and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic effects, especially in older patients, and reduce or stop one agent if they become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Glycopyrronium tosylate with Tolterodine?
MediHelp rates the interaction as moderate. Glycopyrronium tosylate and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, and topical glycopyrronium has some systemic absorption. Combined use may cause additive dry mouth, constipation, urinary retention, blurred vision and heat intolerance.
How serious is the interaction between Glycopyrronium tosylate and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, especially in older patients, and reduce or stop one agent if they become troublesome.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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