Drug interactions
Gold sodium thiomalate + Lisinopril
Severity: Moderate
Gold sodium thiomalate and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Injectable gold has been associated with nitritoid reactions, including flushing, nausea, vomiting and hypotension, and these have been reported more often in patients taking ACE inhibitors. The reactions are usually transient but can be distressing.
What this interaction means in plain words
Gold sodium thiomalate and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism not established; possibly bradykinin-mediated vasodilation potentiated by ACE inhibition.
What to do
Counsel patients about flushing and hypotension after injections and monitor them post-dose. Consider an alternative to the ACE inhibitor if reactions recur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gold sodium thiomalate and Lisinopril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Gold sodium thiomalate with Lisinopril?
MediHelp rates the interaction as moderate. Gold sodium thiomalate and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Injectable gold has been associated with nitritoid reactions, including flushing, nausea, vomiting and hypotension, and these have been reported more often in patients taking ACE inhibitors. The reactions are usually transient but can be distressing.
How serious is the interaction between Gold sodium thiomalate and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about flushing and hypotension after injections and monitor them post-dose. Consider an alternative to the ACE inhibitor if reactions recur.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
