Drug interactions
Gold sodium thiomalate + Ramipril
Severity: Moderate
Gold sodium thiomalate and Ramipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Injectable gold given with ACE inhibitors has been associated with nitritoid reactions such as facial flushing, nausea, vomiting and hypotension. The reactions are uncommon but can be distressing and may occur soon after an injection.
What this interaction means in plain words
Gold sodium thiomalate and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not established; vasodilatory effects of gold may be potentiated by ACE inhibition.
What to do
Monitor patients for flushing and hypotension after gold injections, and consider switching to another antihypertensive or disease-modifying agent if reactions recur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Frequently asked questions
Can I take Gold sodium thiomalate with Ramipril?
MediHelp rates the interaction as moderate. Gold sodium thiomalate and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Injectable gold given with ACE inhibitors has been associated with nitritoid reactions such as facial flushing, nausea, vomiting and hypotension. The reactions are uncommon but can be distressing and may occur soon after an injection.
How serious is the interaction between Gold sodium thiomalate and Ramipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor patients for flushing and hypotension after gold injections, and consider switching to another antihypertensive or disease-modifying agent if reactions recur.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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