Drug interactions
Gold sodium thiomalate + Trandolapril
Severity: Moderate
Gold sodium thiomalate and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Injectable gold has been associated with nitritoid reactions such as flushing, nausea, vomiting and hypotension, and these occur more often in patients on ACE inhibitors. The reactions are uncommon but can be distressing and may lead to syncope.
What this interaction means in plain words
Gold sodium thiomalate and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not well established; ACE inhibition may increase susceptibility to vasomotor reactions to gold.
What to do
Where possible, avoid starting gold injections in patients on ACE inhibitors, or consider an alternative agent. If given, observe the patient after injections and stop gold if nitritoid reactions recur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gold sodium thiomalate and Trandolapril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Gold sodium thiomalate with Trandolapril?
MediHelp rates the interaction as moderate. Gold sodium thiomalate and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Injectable gold has been associated with nitritoid reactions such as flushing, nausea, vomiting and hypotension, and these occur more often in patients on ACE inhibitors. The reactions are uncommon but can be distressing and may lead to syncope.
How serious is the interaction between Gold sodium thiomalate and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, avoid starting gold injections in patients on ACE inhibitors, or consider an alternative agent. If given, observe the patient after injections and stop gold if nitritoid reactions recur.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
