Drug interactions
Gotu kola + Promethazine
Severity: Minor
Gotu kola and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gotu kola has traditionally been reported to have sedative properties and may add to the drowsiness caused by promethazine. Evidence is limited and the effect is likely modest.
What this interaction means in plain words
Gotu kola and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; the mechanism of gotu kola's sedative effect is not well established.
What to do
Counsel patients about possible increased drowsiness and advise against driving until the response is known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Gotu kola with Promethazine?
MediHelp rates the interaction as minor. Gotu kola and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gotu kola has traditionally been reported to have sedative properties and may add to the drowsiness caused by promethazine. Evidence is limited and the effect is likely modest.
How serious is the interaction between Gotu kola and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about possible increased drowsiness and advise against driving until the response is known.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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