Drug interactions
Grapefruit + Ifosfamide
Severity: Minor
Grapefruit and Ifosfamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit inhibits intestinal CYP3A4, which could change ifosfamide exposure. Ifosfamide is given intravenously, so intestinal first-pass inhibition is largely irrelevant, and any hepatic effect is small and unpredictable.
What this interaction means in plain words
Grapefruit and Ifosfamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Intestinal CYP3A4 inhibition by grapefruit components, with little expected effect on intravenous ifosfamide.
What to do
No specific action is required; patients may be advised to avoid large amounts of grapefruit during chemotherapy as a precaution.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Grapefruit with Ifosfamide?
MediHelp rates the interaction as minor. Grapefruit and Ifosfamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit inhibits intestinal CYP3A4, which could change ifosfamide exposure. Ifosfamide is given intravenously, so intestinal first-pass inhibition is largely irrelevant, and any hepatic effect is small and unpredictable.
How serious is the interaction between Grapefruit and Ifosfamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required; patients may be advised to avoid large amounts of grapefruit during chemotherapy as a precaution.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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