Drug interactions
Grapefruit + Lorlatinib
Severity: Moderate
Grapefruit and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice inhibits intestinal CYP3A4 and may raise lorlatinib exposure. Higher concentrations could worsen hyperlipidemia, CNS effects such as mood or cognitive changes, and PR interval prolongation.
What this interaction means in plain words
Grapefruit and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Grapefruit components inhibit intestinal CYP3A4, reducing first-pass metabolism of lorlatinib.
What to do
Advise patients to avoid grapefruit and grapefruit juice during lorlatinib therapy. Monitor lipids and for CNS adverse effects if intake occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Grapefruit with Lorlatinib?
MediHelp rates the interaction as moderate. Grapefruit and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Grapefruit juice inhibits intestinal CYP3A4 and may raise lorlatinib exposure. Higher concentrations could worsen hyperlipidemia, CNS effects such as mood or cognitive changes, and PR interval prolongation.
How serious is the interaction between Grapefruit and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid grapefruit and grapefruit juice during lorlatinib therapy. Monitor lipids and for CNS adverse effects if intake occurs.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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