Drug interactions
Grapefruit + Pimavanserin
Severity: Minor
Grapefruit and Pimavanserin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice inhibits intestinal CYP3A4 and may raise pimavanserin levels. The effect is generally weaker than with strong CYP3A4 inhibitor drugs but varies between people.
What this interaction means in plain words
Grapefruit and Pimavanserin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal CYP3A4 by grapefruit constituents reduces first-pass metabolism of pimavanserin.
What to do
Advise patients to avoid large or regular amounts of grapefruit juice. No dose change is needed unless it is consumed in large amounts alongside QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Grapefruit with Pimavanserin?
MediHelp rates the interaction as minor. Grapefruit and Pimavanserin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice inhibits intestinal CYP3A4 and may raise pimavanserin levels. The effect is generally weaker than with strong CYP3A4 inhibitor drugs but varies between people.
How serious is the interaction between Grapefruit and Pimavanserin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid large or regular amounts of grapefruit juice. No dose change is needed unless it is consumed in large amounts alongside QT risk factors.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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