Drug interactions
Grapefruit + Sorafenib
Severity: Minor
Grapefruit and Sorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit inhibits intestinal CYP3A4 and might modestly raise sorafenib concentrations. Because sorafenib is only partly metabolized by CYP3A4, any effect is likely small.
What this interaction means in plain words
Grapefruit and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Grapefruit constituents inhibit intestinal CYP3A4, potentially reducing first-pass metabolism of sorafenib.
What to do
Routine avoidance is not clearly required, but large daily amounts of grapefruit juice are best avoided. Monitor for sorafenib adverse effects if intake is high.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sorafenib
Frequently asked questions
Can I take Grapefruit with Sorafenib?
MediHelp rates the interaction as minor. Grapefruit and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit inhibits intestinal CYP3A4 and might modestly raise sorafenib concentrations. Because sorafenib is only partly metabolized by CYP3A4, any effect is likely small.
How serious is the interaction between Grapefruit and Sorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Routine avoidance is not clearly required, but large daily amounts of grapefruit juice are best avoided. Monitor for sorafenib adverse effects if intake is high.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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