Drug interactions
Grapefruit + Triamcinolone
Severity: Minor
Grapefruit and Triamcinolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice may raise systemic exposure to triamcinolone, which is cleared mainly by CYP3A4. The effect is likely small with intermittent injections but could increase corticosteroid adverse effects with repeated dosing or high doses.
What this interaction means in plain words
Grapefruit and Triamcinolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal and hepatic CYP3A4 by grapefruit furanocoumarins reduces triamcinolone metabolism.
What to do
No routine action is needed for occasional intake. In patients receiving repeated or high-dose triamcinolone, advise limiting large amounts of grapefruit and watch for Cushingoid effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Frequently asked questions
Can I take Grapefruit with Triamcinolone?
MediHelp rates the interaction as minor. Grapefruit and Triamcinolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice may raise systemic exposure to triamcinolone, which is cleared mainly by CYP3A4. The effect is likely small with intermittent injections but could increase corticosteroid adverse effects with repeated dosing or high doses.
How serious is the interaction between Grapefruit and Triamcinolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed for occasional intake. In patients receiving repeated or high-dose triamcinolone, advise limiting large amounts of grapefruit and watch for Cushingoid effects.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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