Drug interactions
Grapefruit + Vinorelbine
Severity: Minor
Grapefruit and Vinorelbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit inhibits intestinal CYP3A4, which may increase exposure to CYP3A4 substrates. Vinorelbine is given intravenously in most cases, so the effect is likely small, but oral vinorelbine could be affected.
What this interaction means in plain words
Grapefruit and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal CYP3A4 by grapefruit furanocoumarins.
What to do
Advise patients on oral vinorelbine to avoid large amounts of grapefruit products. No action is needed for intravenous dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinorelbine
Frequently asked questions
Can I take Grapefruit with Vinorelbine?
MediHelp rates the interaction as minor. Grapefruit and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit inhibits intestinal CYP3A4, which may increase exposure to CYP3A4 substrates. Vinorelbine is given intravenously in most cases, so the effect is likely small, but oral vinorelbine could be affected.
How serious is the interaction between Grapefruit and Vinorelbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients on oral vinorelbine to avoid large amounts of grapefruit products. No action is needed for intravenous dosing.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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