Drug interactions
Griseofulvin + Hydroxyprogesterone caproate
Severity: Moderate
Griseofulvin and Hydroxyprogesterone caproate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyprogesterone caproate is metabolized partly by CYP3A4. Griseofulvin may modestly lower its levels, which could reduce its effect in preventing preterm birth.
What this interaction means in plain words
Griseofulvin and Hydroxyprogesterone caproate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Griseofulvin induces CYP3A4 and increases clearance of hydroxyprogesterone caproate.
What to do
Avoid griseofulvin in pregnancy where possible, as it is also contraindicated for fetal risk. Choose an alternative antifungal if treatment is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Hydroxyprogesterone caproate?
MediHelp rates the interaction as moderate. Griseofulvin and Hydroxyprogesterone caproate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyprogesterone caproate is metabolized partly by CYP3A4. Griseofulvin may modestly lower its levels, which could reduce its effect in preventing preterm birth.
How serious is the interaction between Griseofulvin and Hydroxyprogesterone caproate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid griseofulvin in pregnancy where possible, as it is also contraindicated for fetal risk. Choose an alternative antifungal if treatment is needed.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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