Drug interactions
Griseofulvin + Levonorgestrel intrauterine
Severity: Minor
Griseofulvin and Levonorgestrel intrauterine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intrauterine system acts mainly locally, with low systemic levonorgestrel levels, so contraceptive efficacy is not meaningfully affected by enzyme induction. Systemic effects such as hormonal side effects might be slightly altered.
What this interaction means in plain words
Griseofulvin and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Griseofulvin induces CYP3A4, which could lower systemic levonorgestrel, but local uterine drug levels dominate the effect.
What to do
No change in therapy is required for the intrauterine system. No backup contraception is generally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Levonorgestrel intrauterine?
MediHelp rates the interaction as minor. Griseofulvin and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The intrauterine system acts mainly locally, with low systemic levonorgestrel levels, so contraceptive efficacy is not meaningfully affected by enzyme induction. Systemic effects such as hormonal side effects might be slightly altered.
How serious is the interaction between Griseofulvin and Levonorgestrel intrauterine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change in therapy is required for the intrauterine system. No backup contraception is generally needed.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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