Drug interactions
Griseofulvin + Lumefantrine
Severity: Moderate
Griseofulvin and Lumefantrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine is metabolized by CYP3A4, and induction may lower its levels. Reduced exposure may lead to treatment failure in malaria.
What this interaction means in plain words
Griseofulvin and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Griseofulvin induces CYP3A4, increasing lumefantrine metabolism.
What to do
Monitor for treatment failure and recrudescence after artemether-lumefantrine therapy. Take the dose with fatty food to optimize absorption.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Lumefantrine?
MediHelp rates the interaction as moderate. Griseofulvin and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine is metabolized by CYP3A4, and induction may lower its levels. Reduced exposure may lead to treatment failure in malaria.
How serious is the interaction between Griseofulvin and Lumefantrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for treatment failure and recrudescence after artemether-lumefantrine therapy. Take the dose with fatty food to optimize absorption.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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