Drug interactions
Griseofulvin + Nelfinavir
Severity: Moderate
Griseofulvin and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir is metabolized via CYP3A4 and CYP2C19, so griseofulvin may lower its concentrations. This may reduce antiviral efficacy.
What this interaction means in plain words
Griseofulvin and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Nelfinavir belongs to Anti Virals.
Why it happens
Griseofulvin induces CYP3A4, increasing nelfinavir clearance.
What to do
Monitor HIV viral load and consider nelfinavir level monitoring. Use an alternative antifungal if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Griseofulvin with Nelfinavir?
MediHelp rates the interaction as moderate. Griseofulvin and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir is metabolized via CYP3A4 and CYP2C19, so griseofulvin may lower its concentrations. This may reduce antiviral efficacy.
How serious is the interaction between Griseofulvin and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and consider nelfinavir level monitoring. Use an alternative antifungal if possible.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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