Drug interactions
Griseofulvin + Parecoxib
Severity: Minor
Griseofulvin and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to valdecoxib, which is partly cleared by CYP3A4 and CYP2C9. Griseofulvin might slightly reduce valdecoxib levels, but a meaningful loss of analgesic effect is unlikely.
What this interaction means in plain words
Griseofulvin and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 induction by griseofulvin may modestly increase valdecoxib clearance.
What to do
No routine adjustment is needed; assess analgesic response and increase the dose within labeled limits only if effect is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Parecoxib?
MediHelp rates the interaction as minor. Griseofulvin and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib is converted to valdecoxib, which is partly cleared by CYP3A4 and CYP2C9. Griseofulvin might slightly reduce valdecoxib levels, but a meaningful loss of analgesic effect is unlikely.
How serious is the interaction between Griseofulvin and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; assess analgesic response and increase the dose within labeled limits only if effect is inadequate.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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