Drug interactions
Griseofulvin + Pazopanib
Severity: Major
Griseofulvin and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may lower pazopanib concentrations and reduce antitumor efficacy. Pazopanib exposure falls with CYP3A4 inducers.
What this interaction means in plain words
Griseofulvin and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Griseofulvin belongs to Anti Fungals; Pazopanib belongs to Oncology.
Why it happens
CYP3A4 induction increases pazopanib clearance.
What to do
Choose a non-inducing antifungal where possible. If coadministered, monitor tumor response and consider pazopanib dose adjustment by specialist advice.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Griseofulvin
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Griseofulvin with Pazopanib?
MediHelp rates the interaction as major. Griseofulvin and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin may lower pazopanib concentrations and reduce antitumor efficacy. Pazopanib exposure falls with CYP3A4 inducers.
How serious is the interaction between Griseofulvin and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-inducing antifungal where possible. If coadministered, monitor tumor response and consider pazopanib dose adjustment by specialist advice.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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