Drug interactions
Griseofulvin + Pentobarbital
Severity: Moderate
Griseofulvin and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates have been reported to lower griseofulvin blood levels, which may reduce antifungal efficacy. Pentobarbital is also an enzyme inducer, so metabolism may contribute.
What this interaction means in plain words
Griseofulvin and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced griseofulvin absorption and possible hepatic enzyme induction by barbiturates lower its exposure.
What to do
Monitor for clinical response to griseofulvin and consider a higher dose or longer course if treatment fails; avoid the combination where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Pentobarbital?
MediHelp rates the interaction as moderate. Griseofulvin and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates have been reported to lower griseofulvin blood levels, which may reduce antifungal efficacy. Pentobarbital is also an enzyme inducer, so metabolism may contribute.
How serious is the interaction between Griseofulvin and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clinical response to griseofulvin and consider a higher dose or longer course if treatment fails; avoid the combination where possible.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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