Drug interactions
Griseofulvin + Pimozide
Severity: Moderate
Griseofulvin and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may lower pimozide concentrations, possibly reducing antipsychotic or tic control. Loss of effect is the main concern.
What this interaction means in plain words
Griseofulvin and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Pimozide belongs to Central Nervous System.
Why it happens
CYP3A4 induction by griseofulvin may increase pimozide metabolism.
What to do
Monitor symptom control, and ECG if the pimozide dose is raised, because of its QT risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Griseofulvin with Pimozide?
MediHelp rates the interaction as moderate. Griseofulvin and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin may lower pimozide concentrations, possibly reducing antipsychotic or tic control. Loss of effect is the main concern.
How serious is the interaction between Griseofulvin and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control, and ECG if the pimozide dose is raised, because of its QT risk.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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