Drug interactions
Griseofulvin + Romidepsin
Severity: Moderate
Griseofulvin and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin is metabolized mainly by CYP3A4. Induction by griseofulvin may lower exposure and reduce antitumor effect.
What this interaction means in plain words
Griseofulvin and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Griseofulvin induces CYP3A4, increasing romidepsin metabolism.
What to do
Use an alternative antifungal where possible, and monitor disease response if the combination is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Romidepsin?
MediHelp rates the interaction as moderate. Griseofulvin and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin is metabolized mainly by CYP3A4. Induction by griseofulvin may lower exposure and reduce antitumor effect.
How serious is the interaction between Griseofulvin and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antifungal where possible, and monitor disease response if the combination is required.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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