Drug interactions
Griseofulvin + Salsalate
Severity: Minor
Griseofulvin and Salsalate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is hydrolyzed to salicylic acid, and griseofulvin has been reported to lower salicylate concentrations. Clinical significance is likely small.
What this interaction means in plain words
Griseofulvin and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism is not established; possible increased salicylate metabolism.
What to do
Monitor clinical response to salsalate and increase the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Salsalate?
MediHelp rates the interaction as minor. Griseofulvin and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salsalate is hydrolyzed to salicylic acid, and griseofulvin has been reported to lower salicylate concentrations. Clinical significance is likely small.
How serious is the interaction between Griseofulvin and Salsalate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to salsalate and increase the dose if needed.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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