Drug interactions
Griseofulvin + Saquinavir
Severity: Moderate
Griseofulvin and Saquinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir has low bioavailability and relies on CYP3A4, so induction by griseofulvin may reduce exposure. This could compromise viral control.
What this interaction means in plain words
Griseofulvin and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Griseofulvin induces CYP3A4 in gut and liver, increasing saquinavir clearance.
What to do
Monitor HIV viral load and consider saquinavir level monitoring. Choose an alternative antifungal if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Saquinavir?
MediHelp rates the interaction as moderate. Griseofulvin and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saquinavir has low bioavailability and relies on CYP3A4, so induction by griseofulvin may reduce exposure. This could compromise viral control.
How serious is the interaction between Griseofulvin and Saquinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and consider saquinavir level monitoring. Choose an alternative antifungal if possible.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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