Drug interactions
Griseofulvin + Sorafenib
Severity: Moderate
Griseofulvin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may reduce sorafenib exposure and compromise anticancer efficacy. Sorafenib exposure is modestly reduced by strong CYP3A4 inducers.
What this interaction means in plain words
Griseofulvin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Sorafenib belongs to Oncology.
Why it happens
Induction of CYP3A4 increases sorafenib clearance.
What to do
Prefer a non-inducing antifungal. If coadministered, monitor tumor response and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Sorafenib
Frequently asked questions
Can I take Griseofulvin with Sorafenib?
MediHelp rates the interaction as moderate. Griseofulvin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin may reduce sorafenib exposure and compromise anticancer efficacy. Sorafenib exposure is modestly reduced by strong CYP3A4 inducers.
How serious is the interaction between Griseofulvin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antifungal. If coadministered, monitor tumor response and tolerability.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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