Drug interactions
Griseofulvin + Tolterodine
Severity: Minor
Griseofulvin and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a CYP3A4 inducer and may lower tolterodine concentrations. Because CYP2D6 is the main clearance route, the effect is usually small, though it may matter in poor CYP2D6 metabolisers.
What this interaction means in plain words
Griseofulvin and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Tolterodine belongs to Genitourinary.
Why it happens
Griseofulvin induces CYP3A4, increasing tolterodine metabolism.
What to do
No empirical dose change is needed. Reassess bladder symptom control and raise the tolterodine dose if the response is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Tolterodine?
MediHelp rates the interaction as minor. Griseofulvin and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin is a CYP3A4 inducer and may lower tolterodine concentrations. Because CYP2D6 is the main clearance route, the effect is usually small, though it may matter in poor CYP2D6 metabolisers.
How serious is the interaction between Griseofulvin and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Reassess bladder symptom control and raise the tolterodine dose if the response is lost.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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