Drug interactions
Griseofulvin + Triazolam
Severity: Minor
Griseofulvin and Triazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a weak inducer of hepatic enzymes and may speed up the breakdown of triazolam. This can lower triazolam exposure and reduce its hypnotic effect, leading to poorer sleep control.
What this interaction means in plain words
Griseofulvin and Triazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Griseofulvin may induce CYP3A4, increasing the metabolic clearance of triazolam.
What to do
Monitor for reduced hypnotic efficacy and titrate the triazolam dose to response. Reassess the dose if griseofulvin is stopped, because triazolam levels may rise again.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Triazolam?
MediHelp rates the interaction as minor. Griseofulvin and Triazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin is a weak inducer of hepatic enzymes and may speed up the breakdown of triazolam. This can lower triazolam exposure and reduce its hypnotic effect, leading to poorer sleep control.
How serious is the interaction between Griseofulvin and Triazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced hypnotic efficacy and titrate the triazolam dose to response. Reassess the dose if griseofulvin is stopped, because triazolam levels may rise again.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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