Drug interactions
Griseofulvin + Vincristine
Severity: Minor
Griseofulvin and Vincristine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may slightly lower vincristine exposure through weak induction of CYP3A4. The effect is theoretical and probably of limited clinical importance.
What this interaction means in plain words
Griseofulvin and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Vincristine belongs to Oncology.
Why it happens
Weak CYP3A4 induction by griseofulvin may increase vincristine metabolism.
What to do
No dose change is usually required; monitor therapeutic response and neurotoxicity as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Griseofulvin with Vincristine?
MediHelp rates the interaction as minor. Griseofulvin and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin may slightly lower vincristine exposure through weak induction of CYP3A4. The effect is theoretical and probably of limited clinical importance.
How serious is the interaction between Griseofulvin and Vincristine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; monitor therapeutic response and neurotoxicity as routine.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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