Drug interactions
Griseofulvin + Vinorelbine
Severity: Minor
Griseofulvin and Vinorelbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may modestly reduce vinorelbine exposure because vinorelbine is cleared by CYP3A4. The clinical effect is expected to be small.
What this interaction means in plain words
Griseofulvin and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Vinorelbine belongs to Oncology.
Why it happens
Weak CYP3A4 induction by griseofulvin may increase vinorelbine metabolism.
What to do
No routine adjustment is needed; monitor response and hematologic toxicity as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Other interactions of Vinorelbine
Frequently asked questions
Can I take Griseofulvin with Vinorelbine?
MediHelp rates the interaction as minor. Griseofulvin and Vinorelbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin may modestly reduce vinorelbine exposure because vinorelbine is cleared by CYP3A4. The clinical effect is expected to be small.
How serious is the interaction between Griseofulvin and Vinorelbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor response and hematologic toxicity as usual.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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