Drug interactions
Griseofulvin + Zaleplon
Severity: Minor
Griseofulvin and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin could reduce zaleplon levels through weak CYP3A4 induction, since zaleplon is mainly metabolized by aldehyde oxidase with a minor CYP3A4 contribution. Reduced hypnotic effect is unlikely to be significant.
What this interaction means in plain words
Griseofulvin and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Zaleplon belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by griseofulvin may slightly increase the minor oxidative clearance of zaleplon.
What to do
No action is usually needed; reassess sleep response if insomnia control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Griseofulvin with Zaleplon?
MediHelp rates the interaction as minor. Griseofulvin and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin could reduce zaleplon levels through weak CYP3A4 induction, since zaleplon is mainly metabolized by aldehyde oxidase with a minor CYP3A4 contribution. Reduced hypnotic effect is unlikely to be significant.
How serious is the interaction between Griseofulvin and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually needed; reassess sleep response if insomnia control worsens.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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